Stimulating effect of pancreatic-like enzymes on the development of the gastrointestinal tract in piglets1
| Autor: | Olena Prykhodko, Björn Weström, D. Gruijc, J. Wolinski, P. Ochniewicz, Olexandr Fedkiv, M. Slupecka, Stefan Pierzynowski |
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| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Gastrointestinal tract biology Crypt Lipid metabolism General Medicine medicine.anatomical_structure Endocrinology Enzyme chemistry Internal medicine Genetics biology.protein medicine Weaning Animal Science and Zoology Amylase Lipase Pancreas Food Science |
| Zdroj: | Journal of Animal Science. 90:311-314 |
| ISSN: | 1525-3163 0021-8812 |
| DOI: | 10.2527/jas.53921 |
| Popis: | Use of nutritional components from the milk and eventually from the solid feed relates to the growth and development of gastrointestinal tract (GIT). We studied the effect of pancreatic-like enzymes [porcine pancreatic enzymes (Creon) or microbial-derived amylase, protease, and lipase] on GIT morphology and lipid absorption in suckling piglets. Both enzyme preparations, in low or high dose, were fed via a stomach tube twice a day for 7 d starting at 8 d of age and controls received vehicle, n = 6. The day after treatments ended, lipid absorption was tested after which pigs were euthanized and GIT was examined. Enzyme cocktails, irrespective of their origin, increased (P < 0.001) triglyceride level in blood. Enzyme preparation affected (P < 0.001) small intestinal mucosal thickness, villi length, and crypt depth and (P < 0.01) mitotic division of enterocytes. In addition, the external administration of pancreatic enzymes stimulated pancreatic growth as observed by increased (P < 0.05) mitotic division of pancreatic cells. The study revealed that pancreatic or pancreatic-like enzymes of microbial origin administrated in the early postperinatal period enhance GIT development and may be used to better prepare the GIT of piglets for milk use and weaning. |
| Databáze: | OpenAIRE |
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