MRI FINDINGS AFTER AN EXPERIMENTAL DISC LESION
| Autor: | L. Kerttula, E. Kääpä, M. Kurunlahti, S. Holm, H. Vanharanta, A. Karttunen, I. Suramo, O. Tervonen |
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| Rok vydání: | 2001 |
| Předmět: | |
| Zdroj: | Journal of Musculoskeletal Research. :95-104 |
| ISSN: | 1793-6497 0218-9577 |
| Popis: | Purpose: A minipig model was used to demonstrate MRI findings in the first three months after an annular disruption. Methods: An incision was made into one of the lumbar discs in each of eight minipigs in the outer and middle parts of the annulus. The remaining intact discs in the lumbar and thoracolumbar regions were used as controls. MR imaging was performed one month and three months after trauma using both a 1.0 T and a 1.5 T MR unit. The histologic analysis was also carried out to demonstrate morphological changes in disc. Results: Eighty-eight percent of the injured discs had a diminished area of bright signal in the nucleus pulposus, also in cases where no signs of trauma in the annulus could be detected in MRI. The degeneration process of the nucleus pulposus was shown to progress during follow-up. High intensity zones were detected in 50% of the injured discs and they tended to appear already after one month follow-up. Histological examination showed that the high-intensity zone contained clusters of nuclear cells originating in the nucleus pulposus. Conclusion: It is concluded that lesions producing high-intensity zones can be induced in an experimental animal model and it can already be detected one month after the trauma. Degeneration process of the nucleus is generally initiated after a peripheral annular lesion. |
| Databáze: | OpenAIRE |
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