Expression of functional trk tyrosine kinase receptors after T cell activation
Autor: | P B Ehrhard, P Erb, U Graumann, B Schmutz, U Otten |
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Rok vydání: | 1994 |
Předmět: | |
Zdroj: | The Journal of Immunology. 152:2705-2709 |
ISSN: | 1550-6606 0022-1767 |
DOI: | 10.4049/jimmunol.152.6.2705 |
Popis: | Increasing evidence indicates that nerve growth factor (NGF), in addition to its neurotrophic actions, exerts specific effects on cells of the immune system. This report show that the CD4-positive T cell line 9/6 expresses trk protooncogene, the signal transducing receptor unit for NGF, after TCR-mediated activation by Ag and APC. This receptor is of functional importance because interaction of NGF with Ag-stimulated 9/6 T cells induced the transcriptional activation of the c-fos gene, a hallmark of the biochemical response to NGF. Our findings that neither mitogen nor Ag stimulation induced the expression of the low affinity NGF receptor in 9/6 T cells indicate that trk alone is sufficient to mediate biologic activity of NGF in T lymphocytes. |
Databáze: | OpenAIRE |
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