Expression of functional trk tyrosine kinase receptors after T cell activation

Autor: P B Ehrhard, P Erb, U Graumann, B Schmutz, U Otten
Rok vydání: 1994
Předmět:
Zdroj: The Journal of Immunology. 152:2705-2709
ISSN: 1550-6606
0022-1767
DOI: 10.4049/jimmunol.152.6.2705
Popis: Increasing evidence indicates that nerve growth factor (NGF), in addition to its neurotrophic actions, exerts specific effects on cells of the immune system. This report show that the CD4-positive T cell line 9/6 expresses trk protooncogene, the signal transducing receptor unit for NGF, after TCR-mediated activation by Ag and APC. This receptor is of functional importance because interaction of NGF with Ag-stimulated 9/6 T cells induced the transcriptional activation of the c-fos gene, a hallmark of the biochemical response to NGF. Our findings that neither mitogen nor Ag stimulation induced the expression of the low affinity NGF receptor in 9/6 T cells indicate that trk alone is sufficient to mediate biologic activity of NGF in T lymphocytes.
Databáze: OpenAIRE
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