Status of Cellular Immunity of Piglets with Porcine Reproductive and Respiratory Syndrome

Autor: K. V. Tarakanova, S. V. Shabunin, T. I. Ermakova, L. Yu. Sashnina, A. G. Shakhov, Yu.Yu. Vladimirova
Rok vydání: 2021
Předmět:
Zdroj: Russian Agricultural Sciences. 47:524-529
ISSN: 1934-8037
1068-3674
DOI: 10.3103/s1068367421050165
Popis: The research outcomes for the status of cellular immunity of piglets with porcine reproductive and respiratory syndrome (PRRS) under the industrial hog farm conditions are reported. The 92-day-old animals were allocated to two experimental groups of clinically healthy piglets and piglets with symptoms of respiratory pathology. The disease etiology was determined based on the results of bacteriological and molecular biological surveys. Lukocyte counts, leukogram patterns, indicators for phagocytosis, T- and B-lymphocyte counts, interleukin 1 beta, tumor necrosis factor, interferon-gamma, and interleukin 10 were determined. In the animals with PRRS manifesting as respiratory pathology, 21.3, 27.1, and 21.3% decreases in counts of segmented neutrophils, eosinophils, and monocytes, respectively, were recorded. A 12.8% increase in the rod neutrophil counts was ascertained. The integrated immunoreactivity indices of white blood cells in the ratios of lymphocytes and eosinophils to monocytes, lymphocytes to eosinophils, lymphocytes to neutrophils, lymphocytes to monocytes, and neutrophils to monocytes increased by 43.5, 53.4, 33.6, 45.7, and 11.1%, respectively. Increases in the absolute and relative counts of T lymphocytes (CD8+) by 50.0 and 27.7%, respectively, and increases in T-lymphocyte counts (CD4+) becoming twofold and 1.4-fold greater corresponded to an increase in the immunoregulatory index by 23.5%. The recorded changes can indicate the activation of a cell link of nonspecific resistance and the formation of adaptive immunity. A 3.9% increase in the IL-1β and especially a 34.8% increase in the IFN gamma were followed by an increase in the activities of absorption and metabolism of neutrophils in the absence of pronounced changes in the TFN-α and IL-10 concentrations in sick piglets. This could indicate a high activity of a cellular link of nonspecific immunity focused on the inactivation and elimination of a pathogen.
Databáze: OpenAIRE
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