Restriction of PD-1 function by cis -PD-L1/CD80 interactions is required for optimal T cell responses

Autor:	Kenji Shimizu, Takeo K. Maeda, Takumi Maruhashi, Il-mi Okazaki, Tatsuya Takemoto, Taku Okazaki, Daisuke Sugiura
Rok vydání:	2019
Předmět:	0301 basic medicine Multidisciplinary biology Effector Chemistry medicine.medical_treatment T cell Immunotherapy Plasma protein binding medicine.disease_cause Autoimmunity Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Immune system 030220 oncology & carcinogenesis PD-L1 medicine biology.protein CD80
Zdroj:	Science. 364:558-566
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.aav7062
Popis:	Sparing T cells from inhibition Programmed cell death 1 (PD-1) is an inhibitory receptor that normally keeps T cell immune responses in check. Immunotherapy targeting PD-1 has proven successful for certain types of cancer, but it remains unclear how PD-1 is regulated. Sugiura et al. found that a costimulatory molecule, CD80, can restrict PD-1 function during the activation of T lymphocytes. Binding of CD80 to the PD-1 ligand PD-L1 in cis on primary activated dendritic cells interfered with the ability of PD-L1 to access PD-1 on T cells, which would otherwise have inhibited T cell activation. Functional insights into PD-L1–CD80 interactions may explain the outcomes of anti–PD-1 and anti–PD-L1 cancer therapy. Science , this issue p. 558
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e71a70dafdc11373939e4d7229a80ce4 https://doi.org/10.1126/science.aav7062 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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