The Role of the Ubiquitin-Proteasome Pathway in Oncogenic

Autor:	Serge Y. Fuchs
Rok vydání:	2002
Předmět:	Pharmacology Cancer Research Cell growth Cell Biology medicine.disease_cause Cell biology medicine.anatomical_structure Oncology Proteasome Ubiquitin medicine biology.protein Molecular Medicine Signal transduction Carcinogenesis Gene Intracellular
Zdroj:	Cancer Biology & Therapy. 1:336-340
ISSN:	1555-8576 1538-4047
Popis:	Oncogenic activation of genes that regulate cell proliferation and survival plays a central role in the development of human cancer. This activation is frequently achieved by the aberrant expression of oncogene products due to the gene amplification, enhanced transcription or stabilization of their mRNA or protein. The ubiquitin-proteasome pathway (UPP) is the key player in the intracellular degradation of regulatory proteins in eukaryotes. UPP controls the abundance and activity of important protein regulators of cellular signal transduction including a variety of cellular proto-oncogenes. Alteration of ubiquitination and degradation of these proto-oncogene proteins often occurs during tumorigenesis and critically contributes to cell decisions as per proliferation/differentiation and survival/death. This article attempts to briefly overview the role of UPP in the regulation of several signal transduction pathways that contribute to development of cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e70d883817b143f56a9063f0f19f4940 https://doi.org/10.4161/cbt.1.4.2 Zobrazit plný text záznamu