| Autor: |
GANESAN SIVAMANI, AZHAGU MADHAVAN SIVALINGAM, ARJUN PANDIAN, SUBRAMANIYAN VAITHILINGAM, GURUSAMY CHELLADURAI, ANDREWS SEKAR |
| Rok vydání: |
2022 |
| Zdroj: |
UTTAR PRADESH JOURNAL OF ZOOLOGY. :48-57 |
| ISSN: |
0256-971X |
| Popis: |
This study used GC-MS analysis and computational biology to examine the diabetic effect of bioactive substances obtained from brown seaweed. Using AutoDock/Vina in Pymol 4.2, the molecular docking of Spatoglossum asperum on the human PPAR- protein was determined and compared to that of the well-known PPAR- agonist Gilbenclamide. The analysis the active components of seaweed extracts is the main focus of the current investigation. 12 substances were discovered using GC-MS analysis and evaluated using AutoDock/Vina against PPAR. Docking tests showed that the existing phytochemical 9-Octadecenoic Acid (Z)-, Octadecyl Ester, obtained from seaweed, has the highest fitness score of -398.9 kcal/mol and may therefore be a potent anti-diabetic drug. This study could result in the creation of brand-new marine nutraceuticals that use brown seaweed to treat a number of diseases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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