In vivo action of Lactococcus lactis subsp. lactis isolate (R7) with probiotic potential in the stabilization of cancer cells in the colorectal epithelium
| Autor: | Fernanda Weber Bordini, Taiciane Gonçalves, Itiane Barcellos Jaskulski, Fernanda Aline de Moura, Simone Pieniz, Julia Neitzel Uecker, Fabiane Borelli Grecco, Robson Andreazza, Wladimir Padilha da Silva, Flávio Anastácio de Oliveira Camargo, Ângela Maria Fiorentini, Natalie Garcia Chaves |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Colorectal cancer Bioengineering Pharmacology medicine.disease_cause 01 natural sciences Applied Microbiology and Biotechnology Biochemistry law.invention 03 medical and health sciences Probiotic Immune system In vivo law 010608 biotechnology medicine 030304 developmental biology 0303 health sciences biology Lactococcus lactis medicine.disease biology.organism_classification Epithelium medicine.anatomical_structure Cancer cell Carcinogenesis |
| Zdroj: | Process Biochemistry. 91:165-171 |
| ISSN: | 1359-5113 |
| Popis: | Recent research has contributed to advances in the treatment and prevention of colorectal cancer (CRC); however, the prevalence and mortality rate remain high. Lactococcus lactis subps. lactis is commonly used for industrial purposes, but there are no in vivo studies evaluating its anticarcinogenic potential. This study aimed to explore the protective effects of an isolate of L. lactis subsp. lactis (R7) from ricotta on CRC as well as evaluatingbiochemical and hematological parameters resulting from treatment. Wistar rats received subcutaneous doses of 1,2-dimethylhydrazine (DMH), what is a chemical carcinogen known to induce this carcinogenesis in experimental models, orally a suspension of R7 (108 colony-forming units. mL−1) and a hypercaloric diet. The results demonstrated a positive effect on the stabilization of the cancer cells induced in the colorectal epithelium, demonstrating anti-carcinogenic potential of R7 against CRC. In addition, an immune response was observed and the biochemical parameters showed that R7 reversed the stress caused by DMH and a hypercaloric diet. The results are promising as regards the behavior of R7 in relation to the treatment of CRC. |
| Databáze: | OpenAIRE |
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