Differential prognostic impact of heart rate in younger and older patients with chronic heart failure
| Autor: | M. Zurek, Marc Gutmann, M.T. Maeder, Urs Jeker, H. P. Brunner-La Rocca, Hans Rickli, M. Pfisterer, R. Handschin, H. Abbuehl, Stefano Muzzarelli |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Pediatrics Ejection fraction Surrogate endpoint business.industry Hazard ratio medicine.disease law.invention law Heart failure Internal medicine Multicenter trial Heart rate medicine Cardiology Artificial cardiac pacemaker Sinus rhythm Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Heart Journal. 34:P1488-P1488 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/eht308.p1488 |
| Popis: | Background: In patients with chronic heart failure (HF), high heart rate (HR) is a marker of poor prognosis, and HR reduction is associated with improved outcomes. However, these data are based on trials including relatively young patients (typically less than 75 years), and there is little information regarding the prognostic role of HR in older HF patients. Accordingly, the aim of the present study was to compare the relationship between HR and outcomes in younger (age 45% and ≤45%) and was not influenced by betablocker use (p value for interaction > 0.33 for all endpoints). Conclusion: In accordance with previous data, we observed better outcomes in younger patients with chronic HF with lower HR compared to those with higher HR. In contrast, an association between HR and outcomes was not seen in older patients with chronic HF. |
| Databáze: | OpenAIRE |
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