The low-dose dexamethasone suppression test in patients with adrenal incidentalomas: comparisons with clinically euadrenal subjects and patients with Cushing's syndrome
| Autor: | P. Kokkoris, J. Kaskarelis, C. Roboti, Stylianos Tsagarakis, V. Vlassopoulou, C. Malagari, C. Alevizaki, N. Thalassinos |
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| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Adenoma business.industry Endocrinology Diabetes and Metabolism Incidentaloma medicine.disease Adrenal Cortex Function Tests Cushing syndrome Endocrinology Dexamethasone suppression test Internal medicine medicine business Dexamethasone Glucocorticoid Hydrocortisone medicine.drug |
| Zdroj: | Clinical Endocrinology. 48:627-633 |
| ISSN: | 0300-0664 |
| DOI: | 10.1046/j.1365-2265.1998.00464.x |
| Popis: | OBJECTIVE Increasing evidence favours subtle glucocorticoid excess in many patients with adrenal incidentalomas. However, existing evidence is based mainly on the overnight dexamethasone suppression test, a test that is commonly abnormal even among clinically euadrenal subjects. The aim of the present study was to evaluate patients with adrenal incidentalomas for subtle glucocorticoid excess by the more specific low-dose dexamethasone test (LDDST). Moreover, since the criteria of what constitutes an abnormal cortisol response following this test have been largely anecdotal, we report our results in comparison with those obtained in clinically euadrenal subjects, and patients with Cushing's syndrome. DESIGN A prospective study of 57 patients with adrenal incidentalomas with CT characteristics highly suggestive of benign adrenocortical adenomas and 85 clinically euadrenal subjects consisting of 54 obese women with BMI > 30 kg/m2 (range 30–54.7), 13 women with BMI |
| Databáze: | OpenAIRE |
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