Ovarian tumors and cysts associated with sexual precocity
| Autor: | William C. Yakovac, Iris T. Jones, Alfred M. Bongiovanni, Walter R. Eberlein |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
endocrine system
medicine.medical_specialty Ovary neoplasm urogenital system medicine.drug_class Granulosa cell Urinary system Physiology Ovary Biology medicine.disease medicine.anatomical_structure Endocrinology Estrogen Theca Internal medicine Pediatrics Perinatology and Child Health medicine Cyst Sexual precocity hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of Pediatrics. 57:484-497 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(60)80257-0 |
| Popis: | Summary Two cases of granulosa cell tumor and one of theca-lutein cyst of the ovary associated with sexual precocity are reported, which demonstrate the difficulty in distinguishing pseudoprecocity from true precocity in the female by the three criteria usually employed: the presence of a mass palpable bimanually, the excretion of large amounts of estrogens, and the absence of urinary gonadotropins when the precocity is produced by a granulosa cell tumor. One of the tumors completely lacked theca cells but contained abundant crystals usually thought to represent the source of estrogens. This finding casts doubt on the belief that the theca cells alone are responsible for estrogen production in ovarian tumors. A review of the literature reveals that granulosa cell tumors in children are less benign than is commonly believed. An analysis of the published cases of ovarian cysts associated with precocity suggests that not all are variants of true sexual precocity. The theca-lutein cyst reported is a possible example of an autonomous functional cyst, resembling five or six others described in the past. |
| Databáze: | OpenAIRE |
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