MO709ASSOCIATION BETWEEN SERUM ELASTIN-DERIVED PEPTIDES AND ABDOMINAL AORTIC CALCIFICATION IN PERITONEAL DIALYSIS PATIENTS: A CROSS-SECTIONAL STUDY
| Autor: | Zhao Shizhu, Lu Guoyuan, Cao Jingyuan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Transplantation
Pathology medicine.medical_specialty biology Cross-sectional study business.industry medicine.medical_treatment Aortic calcification biochemical phenomena metabolism and nutrition bacterial infections and mycoses Peritoneal dialysis carbohydrates (lipids) medicine.anatomical_structure Nephrology Abdominal aortic calcification biology.protein bacteria Medicine Abdomen Mineral metabolism Aortic valve calcification business Elastin |
| Zdroj: | Nephrology Dialysis Transplantation. 36 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/gfab101.0031 |
| Popis: | Background and Aims Peritoneal dialysis (PD) patients experience accelerated arterial aging, which is characterized by elastin degradation. Although elastin-derived peptides (EDPs) have been reported to be associated with vascular diseases, studies on the association between serum EDPs and abdominal aortic calcification (AAC) in PD patients remain limited. Method 126 eligible PD patients were included and first grouped by the presence of AAC by an abdominal computed tomography (CT) scan. Patients with AAC were then grouped into severer and non-severer group according to the annularity of calcification. Logistic regression analysis was conducted to analyze the association between EDPs and AAC or severer AAC. Nomograms were generated to evaluate individualized risk of AAC and severer AAC. Results Serum EDPs were significantly elevated in PD patients compared with healthy controls (interquartile ranges: 37.65-55.02 versus 24.23-39.20 ng/mL; p Conclusion Serum EDPs can predict the presence and severity of AAC in PD patients, indicating the possible roles to recognize PD patients at risk for developing AAC and severer AAC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|