A Simple and Sensitive Poly-1,5-Diaminonaphthalene Modified Sensor for the Determination of Sulfamethoxazole in Biological Samples
| Autor: | Rajendra N. Goyal, Himanshu Chasta |
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| Rok vydání: | 2015 |
| Předmět: |
Drug
Chronic bronchitis Chromatography biology Chemistry media_common.quotation_subject Sulfamethoxazole Sulfonamide (medicine) medicine.disease biology.organism_classification Analytical Chemistry Transplantation Electrochemistry medicine Sulfhemoglobinemia Cyclic voltammetry Bacteria media_common medicine.drug |
| Zdroj: | Electroanalysis. 27:1229-1237 |
| ISSN: | 1040-0397 |
| DOI: | 10.1002/elan.201400688 |
| Popis: | (5-methylisoxazol-3-yl) sul-fanilamide] (Scheme 1a), a sulfonamide drug with anti-bacterial properties, is used for the treatment of humaninfections. Sulfonamide drugs are pervasively used in vet-erinary care and their use without a proper withdrawalperiod can cause accumulation of sulfonamides in eggs,milk, meat and honey as well as in fish [1–3]. Sulfona-mide drugs were used as a first chemotherapeutic agentand employed for the systematic prevention and cure ofbacterial infection in human beings. Activity of the sulfo-namide drugs has been associated with their competitionwith p-aminobenzoic acid (PABA) in the synthesis offolic acid for the growth of bacteria. Therefore, sulfadrugs act by inhibiting the bacterial growth rather thandirectly affecting the bacteria [4]. Recently, it is reportedthat modern classes of sulfonamides and related sulfonylderivatives are served as an effective inhibitor for grow-ing tumor cells, or for the medication of different types ofcancer [5–7]. SMZ has been extensively used for thetreatment of bacterial infections including urinary tract,pneumocystis carinii pneumonia, chronic bronchitis, me-ningococcal meningitis, acute otitis media, Whipples dis-ease and toxoplasmosis as well as in the treatment of op-portunistic infection in transplantation and for AIDS re-lated infection. Nevertheless, SMZ has also been reportedto exhibit different types of side effects, like hypersensi-tivity reaction, gastro-intestinal distribution (mainlynausea and vomiting) and various hematological disor-ders such as thrombocytopenia, sulfhemoglobinemia,megaloblastosis, eosinophilia and agranulocytosis [8–12].Hence, the determination of SMZ in various biologicalsamples and pharmaceutical formulations has been con-sidered of great significance for human health and qualitycontrol.Literature survey reveals that various techniques havebeen used for the determination of SMZ, such as spectro-photometry [13], ratio spectra derivative spectrophotome-try [14], flow injection spectrophotometry [15], gas chro-matography-mass spectrometry [16], capillary electropho-resis [17], liquid chromatography [18], high performanceAbstract: Sulfamethoxazole (SMZ), an antibacterial sul-fonamide drug, has been selectively determined usingpoly-1,5-diaminonaphthalene (p-DAN) modified glassycarbon electrode (GCE). The modified sensor was char-acterized by field emission scanning electron microscopy(FE-SEM), electrochemical impedance spectroscopy(EIS) and cyclic voltammetry (CV). SMZ showed linearresponse in the concentration range of 0.5–150 mMbyusing square wave voltammetry (SWV) and the detectionlimit was found to be 0.05 nM with sensitivity of0.085 mAmM |
| Databáze: | OpenAIRE |
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