Stereoselective synthesis of C-sulfonylated aziridines from halomethyl phenyl sulfone and N-tert-butanesulfinyl imines

Autor:	Zhen Wang, Xinfeng Ren, Ya Li, Fan Yang, Haiji Huang, Desheng Li, Bo Qin
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Trimethylsilyl Base (chemistry) General Chemical Engineering Sodium chemistry.chemical_element General Chemistry Aziridine Sulfone chemistry.chemical_compound chemistry Amide Organic chemistry Stereoselectivity
Zdroj:	RSC Adv.. 4:969-973
ISSN:	2046-2069
DOI:	10.1039/c3ra44174a
Popis:	A highly efficient and stereoselective synthesis of C-sulfonylated aziridines is developed by using a one-step aza-Darzens reaction. When sodium bis(trimethylsilyl)amide (NaHMDS) was used as the base, bromomethyl phenyl sulfone reacted with N-tert-butanesulfinyl imines to afford the 2-sulfonylated aziridine products in very good yields and with stereoselectivities up to 50:1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e6df2158d7fcba8a6777d07ae763df8a https://doi.org/10.1039/c3ra44174a Zobrazit plný text záznamu