Effects of Cyclic RGD Peptide Functionalization on the Quantitative Bone Ingrowth Process in Cellularized Biphasic Calcium Phosphate Ceramics
| Autor: | Joëlle Amédée, R. Bareille, M. Dard, S. Pallu, J. Jeanfils, Jean Christophe Fricain, Laurent Pothuaud, Marie-Christine Durrieu, Martine Renard |
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| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
Materials science Stromal cell Mechanical Engineering Cell Peptide Grafting Phosphate chemistry.chemical_compound Cyclic rgd peptide medicine.anatomical_structure chemistry Mechanics of Materials In vivo medicine Surface modification General Materials Science Biomedical engineering |
| Zdroj: | Key Engineering Materials. :647-650 |
| ISSN: | 1662-9795 |
| Popis: | The aim of this study was to evaluate the in vivo effects of the grafting of cyclo- DfKRG on the early phase of integration of biomaterials made with macroporous hydroxyapatite/b-tricalcium phosphate colonized with autologous bone marrow stromal cells. Non-grafted (-RGD) and grafted (+RGD) biomaterials were implanted in both femoral condyles of rabbits for 2 and 4 weeks. Two weeks after implantation, the global bone formation was higher with +RGD samples (p=0.02). There remained no significant difference 4 weeks after implantation. In conclusion, grafting of cyclo-DfKRG peptide on materials could promote cell colonization and improve osteoconduction during the first stage of the bone cicatrization process. |
| Databáze: | OpenAIRE |
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