| Autor: |
Renato Augusto Moreira de sa, Nicolas Mottet, Andrea Bloch, Silke Johann, Alejandra Abascal, Javiera Fuenzalida, Manuel Guerra Canales, Mary Catherine Cambou, Betania Bohrer, David Baud, Eduard Gratacos Solsona, Mary Higgins, Karen Castillo, Martin Kaufmann, Lucie Sedille, Claudia Grawe, Garanhani Surita, Mariana Horn Scherer, Adriana Gomes Luz, Véronique Lambert, Olga Grechukhina, Fergal D. Malone, Karin Nielsen Saines, Helena Bartels, Melissa Charvet, Marylene Giral, Gustavo Malinger, Cristina Granado, Ann-Christin Tallarek, Joanna Sichitiu, Carolina Prado de França Carvalho, Léo Pomar, Oscar Martinez Perez, Albert I. Ko, Bénédicte Breton, Feras Al-Kharouf, Karoline Aebi-Popp, Kurt Hecher, Jorge A Carvajal, Maria Celeste, Xiang Chen, Marina Moucho, Manon Vouga, Lavinia Schuler-Faccini, Gaston Grant, Anna Goncé, Maria Camila Lopez-Giron, Carolina Borrelli, Romina Capoccia Brugger, Maria Lúcia Rocha Oppermann, Loïc Sentilhes, Uma M. Reddy, Sandra Andrea Heldstab, Béatrice Eggel-Hort, Cécile Monod, Brian Cleary, Gabriel Carles, Michel Boulvain, Leonhard Schäffer, Anis Feki, Susan Knowles, Anne-Claude Muller Brochut, Charles Garabedian, Luigi Raio, Maria Teresa Vieira Sanseverino, Niamh Keating, Lucas Trigo, Jute Richter, Patrick Rozenberg, Annina Haessig, Jan Deprest, Christian R Kahlert, Daniel Surbek, Diogo Ayres de Campos, Dirk Bassler, N. Kölble, Lennart Van der Veeken, Arnaud Toussaint, Monya Todesco Bernasconi, Damien Subtil, Laurent Salomon, Michael Geary, Juan Manuel Burgos-Luna, Ameth Hawkins-Villareal, Sandra A. Heldstab, Irene Hoesli, Eran Hadar, Begoña Martinez de Tejada, Guillaume Favre, Doris Mueller, Olivia Hernandez, Marie-Claude Rossier, Rita Figueiredo, Najeh Hcini, Helene Pelerin, Ron Maymon, Yves Ville, Julien Stiremann, Guillaume Ducarme, Mingzhu Yin, Andrea Papadia, Osorio Wender, Yariv Yogev, Thibaud Quibel, Gaetan Plantefeve, Amanda Dantas-Silva, Marco De Santis, Maria Rosa Vila Hernandez, Pedro Viana Pinto, Luciana Friedrich, Paul Böckenhoff, Mohamed Derouich, Brigitte Strizek, Christophe Poncelet, Panagiotis Kanellos, Tina Fischer, Anda-Petronela Radan, Laura Forcen Acebal, Brigitte Weber, Karina Krajden Haratz, Fernanda Ribeiro-do-Valle, Chloe Moreau, Carmen De Luca, María Fernanda Escobar-Vidarte, Albaro José Nieto Calvache, Alice Panchaud, Camila Giugliani |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| Popis: |
Background: Recent evidence suggests that pregnant women might be at higher risk of severe disease associated with the emerging pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while exposed fetuses/newborns could suffer from preterm birth, growth restriction and neonatal infections. The magnitude of this increased risk and specific risk factors for severity remains unclear. Methods: We performed a case control study comparing pregnant women with severe coronavirus disease 19 (case) to pregnant women with a milder form (controls) enrolled in COVI-Preg international registry cohort between from March 24 to July 26, 2020. Risk factors for severity, obstetrical, fetal and neonatal outcomes were assessed. Findings: A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented a severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of cesarean sections [70.7% (n=53/75)], preterm deliveries [62.7% (n= 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n=31/75)]. Interpretation: Pregnant women, particularly those with associated comorbidities, seem to be at higher risk of severe complications of SARS-CoV-2 infection. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease; complications include cesarean sections, prematurity and neonatal admission to the intensive care unit. Funding Statement: None. Declaration of Interests: The authors declare that they have no conflicts of interest. Ethics Approval Statement: The study was approved by both the Swiss Ethical Board (CER-VD- 2020-00548) and the local ethics boards at each participating center. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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