Thromboseprophylaxe mittels subkutanem rekombinantem Hirudin bei Heparin-induzierter Thrombozytopenie Typ II: Eine Pilotstudie

Autor:	G. Huhle, J. Harenberg, Hoffmann I, D. L. Heene, U. Hoffmann
Rok vydání:	2008
Předmět:	medicine.diagnostic_test business.industry Incidence (epidemiology) General Medicine Heparin medicine.disease Thrombosis Heparin-induced thrombocytopenia Anesthesia medicine Ecarin clotting time Prospective cohort study business medicine.drug Partial thromboplastin time Morning
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 125:686-691
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2007-1024437
Popis:	BACKGROUND Heparin-induced thrombocytopenia (HIT) type II is a severe complication of heparin therapy with a high incidence of thromboembolic events. AIM The aim of this prospective study was to evaluate efficacy and safety of prophylaxis of thromboembolism with subcutaneous r-hirudin (25 mg twice daily) in patients with HIT type II. PATIENTS AND METHODS From 01/06/1997 until 01/08/1999, 19 patients were prospectively included into the study. During subcutaneous r-hirudin application (25 mg twice daily) the activated partial thromboplastin time (aPTT) and ecarin clotting time (ECT) were measured twice daily prior to and 2 hours after the morning injection. RESULTS Ten patients (mean age: 68 years; two men, eight women) with thromboembolic events were intravenously treated with r-hirudin (mean 19.3 days) with a target aPTT of 1.5 to 2.5 times normal values followed by subcutaneous r-hirudin (mean 22.5 days). Five Patients without thromboembolism immediately received subcutaneous r-hirudin (mean 25.9 days; mean age: 61 jahre; two men, three women) after cessation of heparin. Four patients requiring prophylaxis of thromboembolism received subcutaneous r-hirudin (mean 32 days; mean age: 68 years; four women) because of HIT type II in the past. Mean aPTT-values prior to and 1.5-2.5 hours after the morning injection were 1.2 to 1.7 and 2.0 to 2.3 times normal values, respectively. The ECT was prolonged by 1.2 to 1.7 and 2.3 to 2.5 times the upper normal value, respectively. Thromboembolic or bleeding events were not observed during the study. CONCLUSION The subcutaneous application of r-hirudin provides an alternative for primary and secondary prophylaxis of thromboembolism in HIT type II patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e6c1c55adae9045656778815707297c8 https://doi.org/10.1055/s-2007-1024437 Zobrazit plný text záznamu