The crystal structure of first copper(II) complex of a pyridine-2-carboxamidrazone – a potential antitumor agent

Autor:	Daniel L. Rathbone, David C. Billington, Subhash Padhye, Nikhil H. Gokhale, CJ Newton, Carl H. Schwalbe, P. R. Lowe
Rok vydání:	2001
Předmět:	Ligand Stereochemistry Intermolecular force chemistry.chemical_element Crystal structure Electrochemistry Magnetic susceptibility Copper Inorganic Chemistry chemistry.chemical_compound Crystallography chemistry Pyridine Materials Chemistry Physical and Theoretical Chemistry Spectroscopy
Zdroj:	Inorganic Chemistry Communications. 4:26-29
ISSN:	1387-7003
Popis:	The crystal structure of the neutral, distorted square planar copper(II) complex, viz. cis-[dichloro (N1-(2-benzyloxybenzylidene) pyridine-2-carboxamidrazone) copper(II)] (1) is reported which is the first well-characterized copper(II) complex of the series (space group C2/c; a=18.414(5) A ; b=8.6510(10) A ; c=27.091(4) A ; α=90°; β=109.800(17)°; γ=90°; R1=0.0331 wR2=0.0852). The distortion from square planar geometry is thought to arise from the non-equivalent ligand donor set. The Cu–Cl bonds are equivalent with one of the Cl atoms making intermolecular contact at 2.6070 A with adjacent copper rendering a pseudo-square pyramidal geometry around copper. The complex is further characterized by UV/VIS spectroscopy, electrochemistry and magnetic susceptibility measurements. The in vitro antitumor activity of this complex and the parent ligand is determined against the human breast cancer cell-line MCF-7 which revealed that copper complexation renders a highly antiproliferative compound with IC50 value of 3 μM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e6ad44995187ee348a3a5ae648d97c7f https://doi.org/10.1016/s1387-7003(00)00185-4 Zobrazit plný text záznamu Full Text from ScienceDirect