Antineuronal Antibodies in Obsessive-compulsive Disorder: Comparisons in Children with OCD-only, OCD + Chronic tics and OCD + PANDAS

Autor:	Colin D. Gause, Harvey S. Singer, Marco A. Grados
Rok vydání:	2009
Předmět:	medicine.medical_specialty biology Tics Aldolase C Striatum medicine.disease Psychiatry and Mental health medicine.anatomical_structure Endocrinology Gyrus Antigen PANDAS Internal medicine medicine biology.protein Immunohistochemistry Antibody Psychology Neuroscience
Zdroj:	European Psychiatry. 24:1-1
ISSN:	1778-3585 0924-9338
Popis:	We will present a comparison of serum antineuronal antibody profiles in children with OCD-only (n=13), PANDAS + OCD (n=20), CTD + OCD (n=23), and age-matched controls (n=29). Detection methods used to evaluate anti-brain antibodies included immunohistochemistry (striatum), ELISA (BA 9/10, BA 11, caudate, and cingulate gyrus), and Western immunoblotting (BA 9/10, BA 11, caudate, and cingulate gyrus).Immunublotting was further used to assess the presence and concentration of putative antigens identified in post-streptococcal patients, i.e., *- and *-enolase, aldolase C, pyruvate kinase M1 and tubulin. Anti-lysoganglioside GM1 activity was measured by competitive inhibition.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e6a4f2eb4b7a2ea3a38271adfc78f061 https://doi.org/10.1016/s0924-9338(09)70408-0 Zobrazit plný text záznamu