Antineuronal Antibodies in Obsessive-compulsive Disorder: Comparisons in Children with OCD-only, OCD + Chronic tics and OCD + PANDAS
Autor: | Colin D. Gause, Harvey S. Singer, Marco A. Grados |
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Rok vydání: | 2009 |
Předmět: | |
Zdroj: | European Psychiatry. 24:1-1 |
ISSN: | 1778-3585 0924-9338 |
Popis: | We will present a comparison of serum antineuronal antibody profiles in children with OCD-only (n=13), PANDAS + OCD (n=20), CTD + OCD (n=23), and age-matched controls (n=29). Detection methods used to evaluate anti-brain antibodies included immunohistochemistry (striatum), ELISA (BA 9/10, BA 11, caudate, and cingulate gyrus), and Western immunoblotting (BA 9/10, BA 11, caudate, and cingulate gyrus).Immunublotting was further used to assess the presence and concentration of putative antigens identified in post-streptococcal patients, i.e., *- and *-enolase, aldolase C, pyruvate kinase M1 and tubulin. Anti-lysoganglioside GM1 activity was measured by competitive inhibition. |
Databáze: | OpenAIRE |
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