Phomopsols A and B from the Mangrove Endophytic Fungus Phomopsis sp. xy21: Structures, Neuroprotective Effects, and Biogenetic Relationships
| Autor: | Ren-Jie Yan, Zhong-Hui Huang, Jun Wu, Han-Bo Hu, Wan-Shan Li, Li-Wen Tian |
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| Rok vydání: | 2019 |
| Předmět: |
010405 organic chemistry
Stereochemistry Chemistry Organic Chemistry Stereoisomerism Endophytic fungus 010402 general chemistry 01 natural sciences Biochemistry Neuroprotection 0104 chemical sciences Polyketide Phomopsis sp Structure–activity relationship Moiety Physical and Theoretical Chemistry Mangrove |
| Zdroj: | Organic Letters. 21:7919-7922 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.9b02906 |
| Popis: | A polyketide-derived alkaloid featuring a unique 3,4-dihydro-2H-indeno[1,2-b]pyridine 1-oxide motif, named phomopsol A (1), and a highly oxidized polyketide containing a new 3,5-dihydro-2H-2,5-methanobenzo[e][1,4]dioxepine moiety, named phomopsol B (2), were isolated from the Thai mangrove endophytic fungus Phomopsis sp. xy21, together with the related biosynthetic polyketide 3. The structures of 1-3 were unambiguously established by single-crystal X-ray diffraction analysis (Cu Kα), and their neuroprotective effects in PC12 cells were evaluated. The biosynthetic origins of 1-3 are proposed. |
| Databáze: | OpenAIRE |
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