A convergent synthesis of an LTD4 antagonist, RG12525

Autor:	Larry K. Truesdale, Michael K. O'Brien, Adam W. Sledeski
Rok vydání:	1997
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Drug Discovery Synthon Convergent synthesis Antagonist Phenol Tetrazole Alkylation Biochemistry Derivative (chemistry)
Zdroj:	Tetrahedron Letters. 38:1129-1132
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(96)02460-4
Popis:	An efficient, convergent synthesis of an LTD4 antagonist, RG12525 (1) has been achieved through the alkylation of the (2-quinolinylmethoxy)phenol (2) with either a triphenylmethyl protected tetrazole synthon (4a) or with a tetrahydropyranyl derivative (4b). Preparation of synthons 4a and 4b, as well as novel preparation of 2 is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e6949fa8fec707af9aa39bbcfe2d088d https://doi.org/10.1016/s0040-4039(96)02460-4 Zobrazit plný text záznamu Full Text from ScienceDirect