Cardiovascular 18F-fluoride positron emission tomography-magnetic resonance imaging: A comparison study
| Autor: | Christophe Lucatelli, Philip M. Robson, Gillian Macnaught, Mhairi K. Doris, Zahi A. Fayad, Alastair J Moss, Tania Pawade, Piotr J. Slomka, Martin Lyngby Lassen, Jacek Kwiecinski, David E. Newby, Philip D Adamson, Edwin J R van Beek, Marc R. Dweck, Jack P.M. Andrews, Daniel S. Berman |
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| Rok vydání: | 2019 |
| Předmět: |
Aortic valve
Positron emission tomography–magnetic resonance imaging PET-CT business.industry medicine.disease Coronary arteries Stenosis medicine.anatomical_structure medicine Radiology Nuclear Medicine and imaging Myocardial infarction Cardiology and Cardiovascular Medicine business 18f fluoride Nuclear medicine Correction for attenuation |
| Zdroj: | Journal of Nuclear Cardiology. 28:1-12 |
| ISSN: | 1532-6551 1071-3581 |
| DOI: | 10.1007/s12350-019-01962-y |
| Popis: | Background 18F-Fluoride uptake denotes calcification activity in aortic stenosis and atherosclerosis. While PET/MR has several advantages over PET/CT, attenuation correction of PET/MR data is challenging, limiting cardiovascular application. We compared PET/MR and PET/CT assessments of 18F-fluoride uptake in the aortic valve and coronary arteries. Methods and results 18 patients with aortic stenosis or recent myocardial infarction underwent 18F-fluoride PET/CT followed immediately by PET/MR. Valve and coronary 18F-fluoride uptake were evaluated independently. Both standard (Dixon) and novel radial GRE) MR attenuation correction (AC) maps were validated against PET/CT with results expressed as tissue-to-background ratios (TBRs). Visually, aortic valve 18F-fluoride uptake was similar on PET/CT and PET/MR. TBRMAX values were comparable with radial GRE AC (PET/CT 1.55±0.33 vs. PET/MR 1.58 ± 0.34, P = 0.66; 95% limits of agreement − 27% to + 25%) but performed less well with Dixon AC (1.38 ± 0.44, P = 0.06; bias (−)14%; 95% limits of agreement − 25% to + 53%). In native coronaries, 18F-fluoride uptake was similar on PET/MR to PET/CT regardless of AC approach. PET/MR identified 28/29 plaques identified on PET/CT; however, stents caused artifact on PET/MR making assessment of 18F-fluoride uptake challenging. Conclusion Cardiovascular PET/MR demonstrates good visual and quantitative agreement with PET/CT. However, PET/MR is hampered by stent-related artifacts currently limiting clinical application. |
| Databáze: | OpenAIRE |
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