Synthesis of group 6 (chromium, molybdenum, and tungsten) photoCORMs as potential antimicrobial and anticancer agents
| Autor: | Kong Wai Tan, Wee Li Mah, Shiaw Xian Lee, Richard C.S. Wong, Chun Hoe Tan, Yuen Lin Cheow, Kae Shin Sim |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
010405 organic chemistry
Chemistry Ligand chemistry.chemical_element Metal carbonyl Carbon-13 NMR 010402 general chemistry 01 natural sciences 0104 chemical sciences Inorganic Chemistry Metal Chromium Molybdenum visual_art Octahedral molecular geometry Materials Chemistry visual_art.visual_art_medium Proton NMR Physical and Theoretical Chemistry Nuclear chemistry |
| Zdroj: | Inorganica Chimica Acta. 525:120491 |
| ISSN: | 0020-1693 |
| DOI: | 10.1016/j.ica.2021.120491 |
| Popis: | A new ligand 1 (1,10-phenanthrolin-5-amine, N-(2-fluorenylmethylene)) was synthesized and reacted with group 6 metal carbonyls to form UV activable photoCORMs with the formulation of M(1)(CO)4 (M = Cr, Mo, and W, which correspond to 2, 3, and 4, respectively). All synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR, CHN elemental analysis, and single crystal X-ray diffraction. Compounds 2–4 contain four COs bonded to the metal centre displaying distorted octahedral geometry, and the CO can be released via UV (365 nm) illumination. Compound 2 displayed the shortest half-life and shortest CO-releasing rate when tested using modified three-layered myoglobin solution assay. All compounds generally showed no appreciable antibacterial activities, with or without the illumination of UV light, except for 2 which demonstrated considerable antifungal activity against Candida albicans and C. tropicalis. In contrast, compounds 1–4 exhibited potent cytotoxicity against human colorectal cancer cell lines (HT-29 and HCT 116) and 2–4 displayed strong photo-induced cytotoxicity against the same cell lines with remarkedly high selectivity. |
| Databáze: | OpenAIRE |
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