Cryptococcal Endocarditis in a Woman with Metastatic Non-Small Cell Lung Cancer: A Case Report and Review of the Literature

Autor:	Tony Kurian, Jason Peng, Courtney Regan Wagner, Fritzie S. Albarillo
Rok vydání:	2020
Předmět:	Oncology medicine.medical_specialty Heart disease business.industry medicine.medical_treatment medicine.disease respiratory tract diseases Targeted therapy Natural history Internal medicine Carcinoma Medicine Endocarditis Erlotinib business Lung cancer Meningitis medicine.drug
Zdroj:	Journal of Clinical and Medical Case Reports. :1-5
DOI:	10.31487/j.jcmcr.2020.02.06
Popis:	Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have demonstrated improved progression-free survival benefits and decreased treatment-related side effects, and therefore are now considered first-line of treatment of EGFR mutated, metastatic non-small cell lung carcinoma (NSCLC). Cryptococcal endocarditis is an extremely rare clinical entity with only seven reported cases in the literature. Prior cases were seen in patients with a history of rheumatic heart disease or prior valve replacement surgery. Little is known regarding the natural history and optimal management of Cryptococcal endocarditis, given the limited available data. We present a case of Cryptococcal endocarditis and meningitis in a patient with metastatic NSCLC receiving targeted therapy with an EGFR-TKI with no history of significant cardiac disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e683a20f19b38018d8cbfa01bb98b3ba https://doi.org/10.31487/j.jcmcr.2020.02.06 Zobrazit plný text záznamu