| Popis: |
The insect growth regulator, methoprene, is active against the imported fire ant, Solenopsis invicta Buren. This report presents data on the degradation of [ 14 C]methoprene in the imported fire ant. The relative rates of absorption, metabolism, and excretion of methoprene in imported fire ant stages were found in the following order: adults>larvae>pupae>pharate pupae. Metabolism of methoprene by adults and pupae was primarily by O -demethylation to yield the alcohol-ester. Larvae and pharate pupae metabolized methoprene principally by esterase cleavage of the isopropyl ester which yielded the ether-acid. In larvae and pharate pupae there was a rapid increase in methoprene metabolism prior to the pharate pupal transformation and pupal molt. During the molt from pharate pupae to pupae, metabolism of methoprene appeared to occur in the cuticle, resulting in the accumulation of metabolites within and on the cuticle. The retention of these more polar compounds in the cuticle may contribute to the effectiveness of the insect growth regulator. The adults have a direct role in distributing the insect growth regulator and its metabolites, whereas the immatures may serve as a reservoir for maintenance of effective levels of insect growth regulator and active metabolites in the colony. |
