Intrinsic neuromuscular defects in the neurogenic bladder. II. Long-term innervation of the unilaterally decentralized feline bladder base by regenerated cholinergic, increased adrenergic, and emergent probable 'peptidergic' nerves

Autor: Ahmad Elbadawi, Joel I. Franck, Mohamed A. Atta
Rok vydání: 1984
Předmět:
Zdroj: Neurourology and Urodynamics. 3:185-200
ISSN: 1520-6777
0733-2467
DOI: 10.1002/nau.1930030308
Popis: The ultrastructure of muscular innervation of the feline bladder base was studied eight and ten weeks following its decentralization by unilateral sacral ventral rhizotomy. In all samples, there was widespread regeneration of cholinergic axons that displayed initial transsynaptic degeneration a few weeks after the operation, with re-formation of cholinergic neuroeffector junctions. This was associated with reactive sprouting of adrenergic axons leading to adrenergic hyperinnervation, as well as the emergence of a population of cholinergic and adrenergic axons containing strikingly abundant polymorphous large dense-core vesicles that resembled those naturally present in paraganglionic cells, paraneurons, and neurosecretory cells. This increased content of large dense-core vesicles imparts a probable “peptidergic” character to some regenerating and many reactively sprouting adrenergic axons. Our findings suggest that the long-term dysfunction of the parasympathetic-decentralized bladder base is determined by the interplay of reestablished cholinergic, exaggerated adrenergic, and emergent probable “peptidergic” axonal influence and neuroeffector transmission.
Databáze: OpenAIRE