Optimization of the Synthesis of New Antibacterial Compounds with Tris(1-Alkylindol-3-YL)Methylium Fragments

Autor:	Alexey S Trenin, A. Yu. Simonov, Alexey A. Panov, Alexander M. Korolev, Sergey N. Lavrenov
Rok vydání:	2021
Předmět:	Pharmacology Tris 010405 organic chemistry Pharmacology toxicology 01 natural sciences Combinatorial chemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Yield (chemistry) Reagent Drug Discovery Maleimide
Zdroj:	Pharmaceutical Chemistry Journal. 54:1263-1268
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-021-02352-w
Popis:	A new optimal synthetic scheme for new antibacterial compounds combining tris-(1-alkyindol-3-yl)methylium and 3-(indol-1-yl)maleimide in their structures was developed. The proposed method provided a significant increase in the product yield, reduced the labor intensiveness and number of steps, and used readily accessible starting reagents. Agood yield was achieved for 3-(formylindol-1-yl)-4-chloromaleimide, a universal precursor enabling two-step syntheses of target tri(indolyl)methanes and production of an extensive library of analogous potentially active compounds from other 1-alkylindoles and various amines and thiols.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e6706b58cb818f3aa4d20977b133812f https://doi.org/10.1007/s11094-021-02352-w Zobrazit plný text záznamu Plný text ve formátu PDF