Antibodies to inherited &-lipoprotein antigens in the serum of multiply transfused patients

Autor: Kåre Berg, Alexander G. Bearn
Rok vydání: 2008
Předmět:
Zdroj: Clinical Genetics. 1:104-120
ISSN: 1399-0004
0009-9163
DOI: 10.1111/j.1399-0004.1970.tb01972.x
Popis: Sera from 223 multiply transfused patients have been tested for the piesence of prccip:tating antibodies to inherited β-lipoprotein antigens. Twelve sera containing strong precipitins were found, all but one originated from a group of 85 patients with thalassaemia. The last strong antiserum came from 1 of 19 patients with coagulation defects. No precipitating antibodies were found in the sera from 114 patients with different malignant diseares. The specificities of 10 of the 12 antisera were compared with one another, as well as with those of some of the previously described lipoprotein antisera. The existence of the spezificity Ld(a) was confirmed by the finding of two antisera containing antibody to this antigen and one possibly demonstrating the product of an allele to Lda. Two antisera contained precipitins not obviously related to the Ld or Ag antibodies. The remaining antisera demonstrated Ag antigens. Thus, the antigens demonstrated by the isoimmune sera of the present seriey apparently belong to 3 groups of related genetic factors.
Databáze: OpenAIRE
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