A Theoretical Model for Utilizing Mammalian Pharmacology and Safety Data to Prioritize Potential Impacts of Human Pharmaceuticals to Fish
| Autor: | R. T. Williams, J. C. Cook, D. B. Huggett, J. F. Ericson |
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| Rok vydání: | 2003 |
| Předmět: | |
| Zdroj: | Human and Ecological Risk Assessment: An International Journal. 9:1789-1799 |
| ISSN: | 1549-7860 1080-7039 |
| DOI: | 10.1080/714044797 |
| Popis: | Due to the potential for long-term, low-level exposure of environmental species to pharmaceuticals in the environment, concerns over chronic ecotoxicity have been raised. Pharmaceuticals typically have specific enzyme and receptor-based modes of action, which are extensively studied in mammals during drug development. A survey of the literature demonstrated that there is conservation of many enzyme/receptor systems between mammalian and teleost systems. Based on this conservation of enzyme/receptor systems across teleost species, a model has been developed to utilize the information from mammalian pharmacology and toxicology studies to evaluate the potential for chronic receptor mediated responses in fish. In this model, a measured human therapeutic plasma concentration (HTPC) is compared to a predicted steady state plasma concentration (FSSPC) in fish, and an effect ratio (ER = HTPC/FSSPC) is computed. The lower the ER, the greater the potential for a pharmacological response in fish. Data collection and... |
| Databáze: | OpenAIRE |
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