ADRENOCORTICAL AND THYROID FUNCTION IN THE CASTRATE MALE DOG1
| Autor: | Hildegard I. Junker, William F. Ganong |
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| Rok vydání: | 1955 |
| Předmět: | |
| Zdroj: | Endocrinology. 56:105-109 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-56-1-105 |
| Popis: | INTRODUCTION THE extensive and somewhat conflicting literature on the effect of gonadectomy on the thyroid and adrenal has been reviewed by a number of authors (Andersen and Kennedy, 1933; Smith, 1946; Blumenfeld, 1939; Farbman, 1944). Most of the older studies, however, have been limited to observations on the weight and histology of these organs, and there is relatively little data on thyroid and adrenal function. Nowell’s observation (1953) that the gonadectomized rat has a decreased ascorbic acid fall in response to cold stress emphasizes the question of whether or not the pituitary-adrenal axis is capable of responding normally to stress in the castrate animal. The present study was therefore undertaken to determine the effect of castration on adrenocortical and thyroid function in the male dog. MATERIALS AND METHODS Eight adult mongrel dogs weighing 9.6 to 11.5 kg. were castrated. Two weeks later their eosinopenic response to the intramuscular administration of a single dose of 40 international unit... |
| Databáze: | OpenAIRE |
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