Alzheimers Disease: The Novel Finding of Intracellular Biofilms
Autor: | Christos Katsetos, Andrew Touati, Rina M. Allawh, Suresh G. Joshi, Herbert B Allen |
---|---|
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Treponema biology Biofilm medicine.disease biology.organism_classification 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system medicine Extracellular Syphilis Alzheimer's disease Pathological 030217 neurology & neurosurgery Intracellular |
Zdroj: | Journal of Neuroinfectious Diseases. |
ISSN: | 2314-7326 |
Popis: | We previously have found biofilms in the hippocampi of Alzheimer’s disease (AD) post mortem brain specimens. We had seen them in an extracellular location and noted them to be present in the areas of pathological plaque formation. Other investigators have found the presence of spirochetes (Lyme and dental) in affected (AD) brains, and these have been correlated with Treponema pallidum. In a recent historical comparison of the pathology of syphilis, the histological findings of syphilis and AD were shown to be exactly the same. Further, spirochetes have been cultured from the affected brains and have been found to make biofilms and beta amyloid precursor protein. Utilizing the same pathological methods as in our prior study, we have found biofilms in an intracellular location. The similarity of this finding to other diseases has been presented; and, the impact of the “intra” versus the “extra” cellular location is discussed. |
Databáze: | OpenAIRE |
Externí odkaz: |