Lithium benzenetellurolate-induced Reformatsky-type reaction in the presence of cerium trichloride

Autor:	Shin-ichi Fukuzawa, Katsuhiko Hirai
Rok vydání:	1993
Předmět:	chemistry.chemical_classification Ketone Cyclohexanone chemistry.chemical_element Medicinal chemistry Benzaldehyde chemistry.chemical_compound Cerium chemistry Reagent Organic chemistry Stereoselectivity Lithium Reformatsky reaction
Zdroj:	Journal of the Chemical Society, Perkin Transactions 1. :1963
ISSN:	1364-5463 0300-922X
DOI:	10.1039/p19930001963
Popis:	Reformatsky-type reactions with PhTeLi in the presence of CeCl3 proceeded smoothly under mild conditions. The PhTeLi–CeCl3 reagent was particularly efficient for the reactions of sterically hindered and enolizable ketones; in the absence of CeCl3 unsatisfactory yields of the desired β-hydroxy ketone were obtained. It is assumed that CeCl3 reactions involve a cerium enolate intermediate. The stereoselectivity of the reaction between ethyl 2-bromopropionate and benzaldehyde is also described.
Databáze:	OpenAIRE
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