Immunohistochemical and ultrastructural characteristics of the bronchial mucosa during chronic inflammation
| Autor: | Nepomniashchikh Lm, Kononov Av, Nepomniashchikh Gi |
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| Rok vydání: | 1986 |
| Předmět: |
Lamina propria
Chronic bronchitis Pathology medicine.medical_specialty medicine.diagnostic_test business.industry Mucous membrane Inflammation General Medicine medicine.disease General Biochemistry Genetics and Molecular Biology Epithelium medicine.anatomical_structure Immunology Biopsy medicine Bronchitis Immunohistochemistry medicine.symptom business |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 101:377-381 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00835952 |
| Popis: | The local immunity was studied using 31 biopsy samples obtained during bronchoscopy from patients with various forms of chronic bronchitis. Attenuated IgA synthesis by plasmatic cells of bronchial mucosa lamina propria and increased LgG synthesis were established. Enhanced IgG production and penetration of various agents into bronchial mucosa lamina propria cause local immunocomplex reaction involving microcirculatory bed and resulting in perivascular sclerosis. Repeated damaging and sclerotic processes lead to disconnection of epithelial-stromal links and altered cover epithelium differentiation. The role of immunopathologic reactions in the formation of vicious circle underlying morphogenesis of chronic bronchitis is suggested. |
| Databáze: | OpenAIRE |
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