Abstract P337: Lifetime Burden of Traditional Cardiovascular Disease Risk Factors and Incidence of Cancer: The Bogalusa Heart Study
| Autor: | Alexander C. Razavi, Lydia A. Bazzano, Roger S. Blumenthal, Lauren Maniscalco, Seamus P. Whelton, Tekada Ferguson, Xiao-Cheng Wu, Rupert Barshop, Jiang He, Marie Krousel-Wood, Tanika N. Kelly, Camilo Fernandez |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Circulation. 141 |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | Introduction: Cardiovascular disease (CVD) and cancer remain the leading causes of death globally. While these diseases have traditionally been regarded as separate entities, recent evidence points towards shared biological pathways, underlying a need to study CVD and cancer conjointly. We examined the association between CVD risk factors and the incidence of cancer over the life course in a biracial community-based cohort. Methods: The analysis included 1,368 participants of the Bogalusa Heart Study who had at least 3 measurements of CVD risk factors throughout life (57.6% women, 32.8% black, baseline age=10.5 + 3.6 years, median follow-up=38.2 years). CVD risk factors assessed included systolic and diastolic blood pressure, LDL-C, HDL-C, plasma glucose, serum triglycerides, and body mass index (BMI). Cancer cases were ascertained via the Louisiana Tumor Registry. Cox proportional hazards regression assessed the association between CVD risk factors and cancer incidence, adjusting for race, sex, smoking, and blood pressure-, lipid-, and glucose-lowering medications. Results: There were 88 incident cases of cancer, with breast (22.7%), cervical (11.4%), and prostate (9.1%) being the most highly represented cancers. BMI (kg/m 2 ) had the most robust association with incident cancer (HR=5.83, 95% CI: 2.24, 15.19; p=3.0x10 -4 ). We observed a strong association between annualized change in blood pressure per mmHg and hazard of all cancers (for systolic, HR=2.24, 95% CI: 1.50, 3.35; pFigure ). Conclusion: Subclinical increases in adiposity and blood pressure associate with an increased cancer risk, while HDL-C inversely associates with cancer risk, more consistently in women versus men and in blacks versus whites. Control of CVD risk factors beginning in childhood may lead to improved overall cancer prevention in the general population. |
| Databáze: | OpenAIRE |
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