Neuroprotection of the Striatal Dopaminergic Neurons by Tempol in Aged Rat Model of Parkinson's Disease

Autor:	Bal Krishana, Manisha Gautam, Shalu Nim, Ravinder Kumar Saran
Rok vydání:	2014
Předmět:	Pathology medicine.medical_specialty Parkinson's disease business.industry Dopaminergic Striatum Pharmacology medicine.disease Neuroprotection nervous system Toxicity Medicine Neurotoxin Analysis of variance business Aged rat
Zdroj:	International Journal of Physiology. 2:112
ISSN:	2320-608X 2320-6039
DOI:	10.5958/j.2320-608x.2.1.024
Popis:	In the present study, the potential of tempol has been examined as a neuroprotective agent against the toxicity of the 6-hydroxydopamine (6-OHDA) in aged rat. Literature is silent about it. Sprague-Dawley rats were pretreated with tempol and subsequently administered the neurotoxin 6-OHDA into the aged rat striatum. Various behavior and immunohistochemical tests were used to evaluate the neuroprotective effect of tempol. Significant difference in various groups was found (ANOVA, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e62b067a37a813b188841075aa7ee171 https://doi.org/10.5958/j.2320-608x.2.1.024 Zobrazit plný text záznamu