First experimental result with fluorescent X-ray CT based on sheet-beam geometry

Autor: Takao Akatsuka, Jin Wu, Qingkai Huo, Kazuyuki Hyodo, Tohoru Takeda, Hidenori Sato, Tetsuya Yuasa, Thet-Thet Lwin
Rok vydání: 2009
Předmět:
Zdroj: X-Ray Spectrometry. 38:439-445
ISSN: 1097-4539
0049-8246
DOI: 10.1002/xrs.1190
Popis: Fluorescent X-ray computed tomography (FXCT) enables us to reveal the cross-sectional distribution of very low concentration of specific elements, e.g. I, Gd, or Au, in biomedical samples at a spatial resolution of several hundred micrometers, and it has been used to evaluate the states of cerebral perfusion and fatty acid metabolic function of small animals in vivo and ex vivo. However, since the current system employs the data-acquisition scheme of the first-generation type of CT, it requires a huge amount of time to obtain a whole set of projections. In order to overcome the problem, we propose a novel imaging geometry using a sheet incident beam. We performed a proof-of-concept experiment using a preliminary imaging system constructed at beam line BLNE-5A, KEK. The efficacy of the proposed method is demonstrated by the reconstructed images of a physical phantom containing various concentrations of iodine solution and a mouse brain that is extracted after intravenous injection of 127I-IMP for observing the cerebral perfusion and then fixed with formalin. Copyright © 2009 John Wiley & Sons, Ltd.
Databáze: OpenAIRE
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