Intensified Continuous Flow Synthesis and Workup of 1,5-Disubstituted Tetrazoles Enhanced by Real-Time Process Analytics

Autor:	Joerg Sedelmeier, Kurt Püntener, Christian Moessner, Jason D. Williams, Dominique Kummli, Peter Sagmeister, C. Oliver Kappe, Dainis Kaldre
Rok vydání:	2021
Předmět:	010405 organic chemistry Continuous flow business.industry Computer science Process analytical technology Organic Chemistry Flow chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences Process analytics Physical and Theoretical Chemistry Process engineering business
Zdroj:	Organic Process Research & Development. 25:1206-1214
ISSN:	1520-586X 1083-6160
DOI:	10.1021/acs.oprd.1c00096
Popis:	Continuous flow processing presents a solution for the safe and effective formation of 1,5-tetrazoles due to the small reactive inventory and absence of a reactor headspace. This has been exemplifi...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e629850ed6eef79cf2f0b1c867b2fac7 https://doi.org/10.1021/acs.oprd.1c00096 Zobrazit plný text záznamu