| Autor: |
Isha Naik, Gopal Singh Rajawat, Mala D. Menon, Mangal S. Nagarsenker, Korukonda Krishnaprasad |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of Drug Delivery and Therapeutics. 9:79-82 |
| ISSN: |
2250-1177 |
| Popis: |
Vibrating mesh nebulizers (VMN) demonstrate improved efficiency for delivery of inhaled aerosol solutions or suspensions as compared to compressor devices. The added advantages of compactness, portability and functioning as noise-free device makes them of incremental value in Home or Ambulatory settings while managing Severe Obstructive airway disease or delivery of maintenance medications in these cases. This further circumvents the need for multiple devices thereby further improving patient compliance and convenience while delivering acute or maintenance formulations including Glycopyrronium (GLY) and Formoterol (FRM)/Budesonide(BUD) nebulizing solution formulations. To further assess the clinical role and feasibility of FRM-BUD formulation delivery kinetics with or without GLY nebulizing solution through VMN and jet nebulizers for In- & outpatient settings, 2 comparative in-vitro lung deposition studies were carried out utilizing Anderson Cascade impactor at 30 L/min; deposited drug concentrations in different stages were suitably collected and estimated by HPLC. Post-hoc analyses with p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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