Synthesis of a 1,3,4,5-tetrahydrobenz[cd]indole via the Vicarious Nucleophilic substitution of hydrogen

Autor:	Krzysztof Wojciechowski, Jacek Stalewski, Danikiewicz Witold, Mieczysa̵w Ma̧jkosza
Rok vydání:	1997
Předmět:	Indole test chemistry.chemical_classification Hydrogen Vicarious nucleophilic substitution Stereochemistry Organic Chemistry chemistry.chemical_element Ring (chemistry) Biochemistry chemistry.chemical_compound chemistry Drug Discovery Pyrrole Tricyclic
Zdroj:	Tetrahedron. 53:193-214
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(96)00963-5
Popis:	Two approaches to synthesis of 6-methoxy-1,3,4,5-tetrahydrobenz[cd]indol-4-amine 1 were developed Indolic precursor 21 of the tricyclic system was prepared via the VNS reaction, but attempts to execute the C ring closure failed. The other strategy, based on eleboration of the VNS product 30 to a tetrahydronaphtalene system followed with formation of the fused pyrrole ring, proved successful
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e61259ebab568de8d37782da0bcd8a35 https://doi.org/10.1016/s0040-4020(96)00963-5 Zobrazit plný text záznamu Full Text from ScienceDirect