Clinical aspects of medical-genetic counseling and genetic testing of twins, including those from families with family cancer syndrome

Autor:	L.Z. Polishchuk, Z.I. Rossokha, O.V. Paliychuk
Rok vydání:	2016
Předmět:	Cancer syndrome medicine.medical_specialty medicine.diagnostic_test business.industry Family medicine Genetic counseling medicine medicine.disease business Genetic testing
Zdroj:	HEALTH OF WOMAN. :142-147
ISSN:	2307-5074 1992-5921
DOI:	10.15574/hw.2016.115.142
Popis:	The cases of benign and malignant tumors development in family trees of cancer patients and in sister twins are described. The results of complex examination and medical genetic counseling of examined persons are discussed. Polymorph variants T-397C, A-351G of the gene ERS1 (СC- and GG-genotypes), genotype AG of the gene Cyp2D6 were determined that suggest the requirement for medical-genetic counseling and molecular-genetic testing for determination of gene ERS1 polymorphism in females from families with family cancer history, in particular, in twins. Key words: family tree, proband, twins, hereditary predisposition, gene ERS1 polymorphisms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e5fe5cacb136b24a02cd3361ed60e9cc https://doi.org/10.15574/hw.2016.115.142 Zobrazit plný text záznamu