Palladium-Catalyzed Peripheral Arylation of 5-Pyrazolones via Enolizable Bond Protection

Autor:	Yun Soo Bae, Guncheol Kim, Hye Rin Bin, Kee In Lee
Rok vydání:	2011
Předmět:	Organic Chemistry Pyrazolone chemistry.chemical_element Keto–enol tautomerism Chemical synthesis Enol Tautomer Combinatorial chemistry Catalysis chemistry.chemical_compound Suzuki reaction chemistry medicine Pyrazolones Palladium medicine.drug
Zdroj:	Synthesis. 2011:1783-1791
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0030-1260018
Popis:	Peripheral cross-coupling of the enol form of the 5-pyrazolone scaffold with arylboronic acids promoted by [PdCl 2 (dppf)] afforded the arylated products in good yields. In this coupling, the protection of the enolizable hydroxyl group of pyrazolone is a prerequisite for ensuring the Suzuki-Miyaura cross-coupling. A particular feature of this process is that it enables the synthesis of 5-hydroxy-3-biphenyl and -terphenylpyrazole derivatives with structural diversity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e5f18f077620a121660ddc4dfd47b3a2 https://doi.org/10.1055/s-0030-1260018 Zobrazit plný text záznamu