A Biological Profile of a Nonsteroidal Antiandrogen, SCH 13521 (4'–Nitro–3'–Trifluoromethylisobutyranilide)1
| Autor: | Rudolph O. Neri, Patricia Koziol, Florance K, Van Cleave S |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Testosterone propionate
medicine.medical_specialty medicine.drug_class Anogenital distance Cyproterone acetate Dehydroepiandrosterone Antiandrogen Andrology chemistry.chemical_compound Endocrinology chemistry Dihydrotestosterone Internal medicine medicine heterocyclic compounds Androstenedione Testosterone medicine.drug |
| Zdroj: | Endocrinology. 91:427-437 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-91-2-427 |
| Popis: | Sch 13521 (4'–nitro–3'–trifluoromethylisobutyranilide) at daily doses from 1–50 mg/kg reduced seminal vesicles and ventral prostate wt of intact male rats treated orally for 1–3 weeks. No alterations in sex structures of female rats were observed with doses as high as 50 mg/kg. Sch 13521 antagonized the effects of testosterone, testosterone propionate, androstenedione, and dihydrotestosterone on seminal vesicles and ventral prostate wt in castrated rats as well as the effects of hCG in hypophysectomized rats. A comparative study in castrated rats revealed that Sch 13521 was equipotent to cyproterone acetate (CPA) as an antiandrogen. However, when Sch 13521 was given to gravid rats, days 16–19, it reduced the anogenital distance in male fetuses and altered the normal development of the scrotum and penis, but unlike CPA, Sch 13521 did not effect parturition time. In the majority of these male rats, hypospadias and vaginal tracts were present and ventral prostates and seminal vesicles were absent or markedly... |
| Databáze: | OpenAIRE |
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