Transgenic rats in hypertension research

Autor: Martin Paul, J Wagner, K. Zeh
Rok vydání: 1996
Předmět:
Zdroj: Molecular Reviews in Cardiovascular Medicine ISBN: 9789401065252
DOI: 10.1007/978-94-009-0083-7_7
Popis: The genetic basis of numerous diseases has been studied by taking advantage of the new techniques offered by molecular biology and medicine. The contributions of classical genetic studies with analyses of linkage between phenotypic changes and genotypes have been sophisticated ways of identifying areas on the genome related to pathological alterations [1]. An alternative experimental approach is to establish transgenic animals harbouring candidate genes for the development of selected diseases. In cardiovascular medicine, several candidate genes for the development of cardiovascular disorders have now been identified which can be used for transgenic experiments. These include hypertension-related candidates such as renin [2] and the angiotensin converting enzyme (ACE) [3,4].
Databáze: OpenAIRE