Heterotrimeric Gα12/13proteins in kidney injury and disease
| Autor: | Elena Tutunea-Fatan, Lakshman Gunaratnam, Bradley M. Denker, Jasper C. Lee |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Kidney Cell type Physiology G protein Effector Acute kidney injury Biology medicine.disease Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Cell surface receptor 030220 oncology & carcinogenesis Heterotrimeric G protein medicine Signal transduction |
| Zdroj: | American Journal of Physiology-Renal Physiology. 318:F660-F672 |
| ISSN: | 1522-1466 1931-857X |
| DOI: | 10.1152/ajprenal.00453.2019 |
| Popis: | Gα12and Gα13are ubiquitous members of the heterotrimeric guanine nucleotide-binding protein (G protein) family that play central and integrative roles in the regulation of signal transduction cascades within various cell types in the kidney. Gα12/Gα13proteins enable the kidney to adapt to an ever-changing environment by transducing stimuli from cell surface receptors and accessory proteins to effector systems. Therefore, perturbations in Gα12/Gα13levels or their activity can contribute to the pathogenesis of various renal diseases, including renal cancer. This review will highlight and discuss the complex and expanding roles of Gα12/Gα13proteins on distinct renal pathologies, with emphasis on more recently reported findings. Deciphering how the different Gα12/Gα13interaction networks participate in the onset and development of renal diseases may lead to the discovery of new therapeutic strategies. |
| Databáze: | OpenAIRE |
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