Synthesis and Antitumor Activity of Dehydroepiandrosterone Derivatives on Es-2, A549, and HepG2 Cells in vitro

Autor:	Hu-Ri Piao, Bai-Jun Ye, Ji-Xing Nan, Yan Wu, Zhen-Hua Lin, Xue-Kun Liu
Rok vydání:	2012
Předmět:	Pharmacology Antitumor activity A549 cell Chemistry Organic Chemistry Dehydroepiandrosterone Inhibitory postsynaptic potential Biochemistry In vitro Cell culture Hepg2 cells Drug Discovery Molecular Medicine MTT assay
Zdroj:	Chemical Biology & Drug Design. 79:523-529
ISSN:	1747-0277
DOI:	10.1111/j.1747-0285.2011.01311.x
Popis:	A series of dehydroepiandrosterone derivatives containing an acid ester was synthesized and evaluated for their antitumor activity on ES-2, A549, and HepG2 cells by the MTT assay. Most compounds showed antitumor activity, while compounds 1c, 2i, and 2o exhibited more potential inhibitory effects compared with dehydroepiandrosterone on ES-2 cells, A549 cells, and HepG2 cells, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e5e2797b938ef3855d2880cace3f66fc https://doi.org/10.1111/j.1747-0285.2011.01311.x Zobrazit plný text záznamu Plný text ve formátu PDF