Autoantibodies against nephrin elucidate a novel autoimmune phenomenon in proteinuric kidney disease
| Autor: | Lerner G, Sushrut S. Waikar, Jonathan P. Troost, Laurence H. Beck, Andrew J. R. Watts, Sampson M, Anil Chandraker, Anna Greka, Jennifer Yee, Miroslav Sekulic, Chen J, Astrid Weins, Keith Keller, Leonardo V. Riella, Mariam P. Alexander, Collins Ab, Ivy A. Rosales, Helmut G. Rennke, Damian Fermin, Joel Henderson |
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| Rok vydání: | 2021 |
| Předmět: |
Kidney
Proteinuria biology urogenital system business.industry Autoantibody Renal function urologic and male genital diseases medicine.disease female genital diseases and pregnancy complications Podocyte Nephrin medicine.anatomical_structure Immunology medicine biology.protein medicine.symptom business Nephrotic syndrome Kidney disease |
| DOI: | 10.1101/2021.02.26.21251569 |
| Popis: | Dysfunction of podocytes, cells critical for glomerular filtration, underlies proteinuria and kidney failure. Genetic forms of proteinuric kidney disease can be caused by mutations in several podocyte genes, including nephrin, a critical component of the kidney filter. In contrast, the etiology of acquired acute-onset nephrotic syndrome has remained elusive. Here we identify autoantibodies against nephrin in serum and glomeruli of a subset of adults and children with non-congenital acute nephrotic syndrome. Our findings align with published experimental animal studies and elucidate a novel autoimmune phenomenon in proteinuric kidney disease interfering with glomerular filter integrity. |
| Databáze: | OpenAIRE |
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