Diabetic Retinopathy
| Autor: | Scot R. Kimball, Alistair J. Barber, Ian A. Simpson, Willard M. Freeman, David A. Antonetti, Leonard S. Jefferson, Lakshman Sandirasegarane, Sarah K. Bronson, Mark Kester, J. Kyle Krady, Thomas W. Gardner, Christopher C. Norbury, Patrick G. Quinn, Kathryn F. LaNoue |
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| Rok vydání: | 2006 |
| Předmět: |
Retina
medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment Microangiopathy Retinal Disease Diabetic retinopathy medicine.disease Surgery chemistry.chemical_compound medicine.anatomical_structure chemistry Diabetes mellitus Internal Medicine medicine business Intensive care medicine Retinopathy |
| Zdroj: | Diabetes. 55:2401-2411 |
| ISSN: | 1939-327X 0012-1797 |
| Popis: | Diabetic retinopathy remains a frightening prospect to patients and frustrates physicians. Destruction of damaged retina by photocoagulation remains the primary treatment nearly 50 years after its introduction. The diabetes pandemic requires new approaches to understand the pathophysiology and improve the detection, prevention, and treatment of retinopathy. This perspective considers how the unique anatomy and physiology of the retina may predispose it to the metabolic stresses of diabetes. The roles of neural retinal alterations and impaired retinal insulin action in the pathogenesis of early retinopathy and the mechanisms of vision loss are emphasized. Potential means to overcome limitations of current animal models and diagnostic testing are also presented with the goal of accelerating therapies to manage retinopathy in the face of ongoing diabetes. |
| Databáze: | OpenAIRE |
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