Sexual differentiation of kisspeptin neurons responsible for sex difference in gonadotropin release in rats

Autor:	Tamami Homma, Junko Tomikawa, Yoshihisa Uenoyama, Hiroko Tsukamura, Kei-ichiro Maeda
Rok vydání:	2010
Předmět:	endocrine system medicine.medical_specialty Sexual differentiation medicine.drug_class General Neuroscience Biology Androgen General Biochemistry Genetics and Molecular Biology Kisspeptin Endocrinology History and Philosophy of Science Estrogen Internal medicine medicine Anteroventral periventricular nucleus Gonadotropin Luteinizing hormone hormones hormone substitutes and hormone antagonists Defeminization
Zdroj:	Annals of the New York Academy of Sciences. 1200:95-103
ISSN:	0077-8923
DOI:	10.1111/j.1749-6632.2010.05645.x
Popis:	The brain mechanism regulating GnRH/luteinizing hormone (LH) release is sexually differentiated in rodents. Estrogen induces a GnRH/LH surge in females but not in males. Kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) have been reported to be sexually dimorphic and suggested to be involved in the GnRH/LH surge generation. Neonatal testicular androgen may cause the reduction of AVPV kisspeptin expression and a lack of LH surge in male rats. Thus, it is plausible that perinatal testicular androgen causes defeminization of the AVPV kisspeptin system, resulting in the loss of the surge system in male rats.
Databáze:	OpenAIRE
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