| Autor: |
HESTI RIASARI, DIKI PRAYUGO WIBOWO, NOVI IRWAN FAUZI |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
International Journal of Applied Pharmaceutics. :50-55 |
| ISSN: |
0975-7058 |
| DOI: |
10.22159/ijap.2022.v14s5.05 |
| Popis: |
Objective: This study describes the potential antidiabetic activity of ethanol extracts of Kabau leaves (Archidendron bubalinum) Methods: Extraction was done using the maceration method with 96% ethanol as solvent. The simplicia and extracts were characterized, screened for phytochemicals using Thin Layer Chromatography (TLC). Blood glucose levels were examined by GOD-PAP enzymatic method. Wistar rat was induced by alloxan (120 mg/kg BW i. p) to hyperglycemic condition, the dose variations of Kabau leaves extract i. e 250, 500, and 1000 mg/kg BW (p. o). The data was statistically tested using one-way ANOVA with a confidence level of (p126 mg/dl) and a significant increase in blood glucose levels compared to the control group. MDA levels in test animals given a dose of 1000 mg/kg BW was 0.024±0.003. Conclusion: Ethanol extract of Kabau leaves can reduce blood glucose levels in hyperglycemic rats by 33% at a dose of 1000 mg/kg BW. The results of one-way ANOVA (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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