Hemisynthesis of 132,173-cyclomesopheophorbide-a-enol

Autor:	Mitra (Mortezaei-Rad) Khalesi, J. William Louda
Rok vydání:	2011
Předmět:	Chemistry Organic Chemistry Condensation chemistry.chemical_element Mass spectrometry Biochemistry Sulfur Enol law.invention Matrix (chemical analysis) chemistry.chemical_compound Column chromatography law Phase (matter) Drug Discovery Organic chemistry Crystallization
Zdroj:	Tetrahedron Letters. 52:1078-1081
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2010.12.079
Popis:	Cyclopheophorbides are often major chlorophyll-a degradation products in biogeochemical situations. Authentic standards are unavailable and facile generation of pure compounds is required. 132,173-Cyclomesopheophorbide-a-enol (mesoCYCLO) was prepared in moderate yields via a known Dieckmann-like condensation of mesopyropheophorbide-a methyl ester (mpPBIDaME). MesoCYCLO was purified by flash chromatography over a polymeric reversed phase (PRP-1™) material, negating the requirement for a crystallization step. Structural verification included ultraviolet-visible spectrometry, high resolution matrix (sulfur/CS2) assisted laser desorption mass spectrometry, and nuclear magnetic resonance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e5d623e0a7de61f8f2fd15f8ea969bbf https://doi.org/10.1016/j.tetlet.2010.12.079 Zobrazit plný text záznamu Full Text from ScienceDirect